Gene Synthesis Service with Free Codon Optimization

Since our first gene was synthesized back in 2004, Epoch Life Science (originally Epoch Biolabs) has evolved to become one of the most dedicated gene synthesis companies. A plethora of references from peer-reviewed journals as well as patents, see below, certainly tells you more about our capability. Every project is taken seriously at Epoch with a focus on accuracy, speed and minimum cost. Our PhD experts go extra miles to help you design your projects with their extensive expertise in protein biochemistry, structural biology, cell biology and molecular biology. Minimizing your risk of wasting money, more importantly, saving your time and efforts in reaching your final goals. Our dedication can not always be matched elsewhere. Epoch Life Science can accommodate hundreds of projects simultaneously with hundreds of well trained associates. High GC, hairpin, tandem repeats will not deter us. Your gene smith can make any gene you can dream of. We are here to accelerate your research.

Detailed Specifications:

  • Full Service: Cloned into our standard vector pBlueScript or pUC and sequence verified. Minimum order for each small gene is $150.00. Guaranteed low price, email or call for quote. 
  • Optional codon optimization with no extra charges are included for both services.
  • Single-host vs. multi-host co-don optimization for over-expression 
  • Complete sequencing* (for full service only), 100% accuracy
  • As fast as 6 days, on average 2-3 week turn around time**

Turn Around Time:

* Under 7 business days for synthetic fragments. Full Serviced (cloned and sequence verified) are as follows:
Gene size  Average Turn Around Time***
< 1kp 6-12 business days
1-3kb 10-17 business days
3-10kb 15-25 business days

Gene Variant:

Gene size  Average Turn Around Time***
< 1kp 6 business days
1-3kb 6 business days
3-10kb 6 business days
* Only when ordered together with gene synthesis

Custom Cloning:

Service  Average Turn Around Time***
Subcloning 6 business days
cDNA Clone 6 business days
Knockout/KnockIn 6 business days


For a non binding quote of our Full Service for your particular project, email your sequence to

Other Epoch Life Science Services You might be interested in:

Custom Cloning                    Site-Directed Mutagenesis                 DNA Sequencing          Protein Expression Optimization


References citing our gene synthesis services:

Adameyko, I., F. Lallemend, A. Furlan, N. Zinin, S. Aranda, S.S. Kitambi, A. Blanchart, R. Favaro, S. Nicolis, and M. Lübke. "Sox2 and Mitf Cross-Regulatory Interactions Consolidate Progenitor and Melanocyte Lineages in the Cranial Neural Crest." Development 139, no. 2 (2012): 397-410.

Alder, A., I. Holdermann, P. Beyer, and S. Al-Babili. "Carotenoid Oxygenases Involved in Plant Branching Catalyse a Highly Specific Conserved Apocarotenoid Cleavage Reaction." Biochem. J 416, (2008): 289-296.

Alvarez, J.P., I. Pekker, A. Goldshmidt, E. Blum, Z. Amsellem, and Y. Eshed. "Endogenous and Synthetic Micrornas Stimulate Simultaneous, Efficient, and Localized Regulation of Multiple Targets in Diverse Species." The Plant Cell Online 18, no. 5 (2006): 1134-1151.

Amanda, J., J.M. Hyser, V.V. Keasler, Y. Cang, and B.L. Slagle. "Hepatitis B Virus Regulatory Hbx Protein Binding to Ddb1 Is Required but Is Not Sufficient for Maximal Hbv Replication." Virology, (2012).

Antonczak, A.K., Z. Simova, and E.M. Tippmann. "A Critical Examination of Escherichia Coli Esterase Activity." Journal of Biological Chemistry 284, no. 42 (2009): 28795-28800.

Antonczak, A.K., Z. Simova, I.T. Yonemoto, M. Bochtler, A. Piasecka, H. Czapińska, A. Brancale, and E.M. Tippmann. "Importance of Single Molecular Determinants in the Fidelity of Expanded Genetic Codes." Proceedings of the National Academy of Sciences 108, no. 4 (2011): 1320-1325.

Araújo, J.A. "Produção De Quimosina B De Bos Taurus Em Pichia Pastoris." (2008).

Atsumi, S., A.F. Cann, M.R. Connor, C.R. Shen, K.M. Smith, M.P. Brynildsen, K.J.Y. Chou, T. Hanai, and J.C. Liao. "Metabolic Engineering of Escherichia Coli for 1-Butanol Production." Metabolic engineering 10, no. 6 (2008): 305-311.

Avedillo Diez, I., D. Zychlinski, E.G. Coci, M. Galla, U. Modlich, R.A. Dewey, A. Schwarzer, T. Maetzig, N. Mpofu, and E. Jaeckel. "Development of Novel Efficient Sin Vectors with Improved Safety Features for Wiskott-Aldrich Syndrome Stem Cell Based Gene Therapy." Molecular pharmaceutics, (2011).

Azizi, A., A. Arora, A. Markiv, D.J. Lampe, T. Miller, and A.S. Kang. "Ribosome Display of Combinatorial Antibody Libraries Derived from Mice Immunised with Heat-Killed Xylella Fastidiosa and the Selection of Mopb-Specific Single-Chain Antibodies." Applied and environmental microbiology, (2012).

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D'Aoust, M.A., P.O. Lavoie, M.M.J. Couture, S. Trépanier, J.M. Guay, M. Dargis, S. Mongrand, N. Landry, B.J. Ward, and L.P. Vézina. "Influenza Virus‐Like Particles Produced by Transient Expression in Nicotiana Benthamiana Induce a Protective Immune Response against a Lethal Viral Challenge in Mice." Plant biotechnology journal 6, no. 9 (2008): 930-940.

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Dinh, T., and T.G. Bernhardt. "Using Superfolder Green Fluorescent Protein for Periplasmic Protein Localization Studies." Journal of bacteriology 193, no. 18 (2011): 4984-4987.

Evans, R.M., E.M. Behiry, L.H. Tey, J. Guo, E.J. Loveridge, and R.K. Allemann. "Catalysis by Dihydrofolate Reductase from the Psychropiezophile Moritella Profunda." ChemBioChem 11, no. 14 (2010).

Franz, AWE, N. Jasinskiene, I. Sanchez‐Vargas, AT Isaacs, MR Smith, CCH Khoo, MS Heersink, AA James, and KE Olson. "Comparison of Transgene Expression in Aedes Aegypti Generated by Mariner Mos1 Transposition and Φc31 Site‐Directed Recombination." Insect Molecular Biology, (2011).

Galazka, J., B. Striepen, and B. Ullman. "Adenosine Kinase from< I> Cryptosporidium Parvum</I>." Molecular and biochemical parasitology 149, no. 2 (2006): 223-230.

Guillaumond, F., A. Gréchez-Cassiau, M. Subramaniam, S. Brangolo, B. Peteri-Brünback, B. Staels, C. Fiévet, T.C. Spelsberg, F. Delaunay, and M. Teboul. "Krüppel-Like Factor Klf10 Is a Link between the Circadian Clock and Metabolism in Liver." Molecular and cellular biology 30, no. 12 (2010): 3059-3070.

Gurda, B.L., K.N. Parent, H. Bladek, R.S. Sinkovits, M.A. DiMattia, C. Rence, A. Castro, R. McKenna, N. Olson, and K. Brown. "Human Bocavirus Capsid Structure: Insights into the Structural Repertoire of the Parvoviridae." Journal of virology 84, no. 12 (2010): 5880-5889.

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Harris, B., I. Pereira, and E. Parkin. "Targeting Adam10 to Lipid Rafts in Neuroblastoma Sh-Sy5y Cells Impairs Amyloidogenic Processing of the Amyloid Precursor Protein." Brain research 1296, (2009): 203-215.

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Ingaramo, M., and D. Beckett. "Selectivity in Post-Translational Biotin Addition to Five Human Carboxylases." Journal of Biological Chemistry 287, no. 3 (2012): 1813-1822.

Isaacs, A.T., F. Li, N. Jasinskiene, X. Chen, X. Nirmala, O. Marinotti, J.M. Vinetz, and A.A. James. "Engineered Resistance to Plasmodium Falciparum Development in Transgenic Anopheles Stephensi." PLoS pathogens 7, no. 4 (2011): e1002017.

Jack, B.H.A., and M. Crossley. "Gata Proteins Work Together with Friend of Gata (Fog) and C-Terminal Binding Protein (Ctbp) Co-Regulators to Control Adipogenesis." Journal of Biological Chemistry 285, no. 42 (2010): 32405-32414.

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Moreira, S., F. Andrade, L. Domingues, and M. Gama. "Development of a Strategy to Functionalize a Dextrin-Based Hydrogel for Animal Cell Cultures Using a Starch-Binding Module Fused to Rgd Sequence." BMC biotechnology 8, no. 1 (2008): 78.

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Neuteboom, L.W., K.O. Matsumoto, and D.A. Christopher. "An Extended Ae-Rich N-Terminal Trunk in Secreted Pineapple Cystatin Enhances Inhibition of Fruit Bromelain and Is Posttranslationally Removed During Ripening." Plant physiology 151, no. 2 (2009): 515-527.

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Nunes, A.C.S., D.C. Kalkmann, and F.J.L. Aragao. "Folate Biofortification of Lettuce by Expression of a Codon Optimized Chicken Gtp Cyclohydrolase I Gene." Transgenic research 18, no. 5 (2009): 661-667.

O'Connor, T.P., J.M. Saucier, D. Daniluk, B.A. Stillman, R. Krah, Y. Rikihisa, Q. Xiong, M.J. Yabsley, D.S. Adams, and P.P.V.P. Diniz. "Evaluation of Peptide-and Recombinant Protein-Based Assays for Detection of Anti-Ehrlichia Ewingii Antibodies in Experimentally and Naturally Infected Dogs." American journal of veterinary research 71, no. 10 (2010): 1195-1200.

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Oka, T., E. Remue, K. Meerschaert, B. Vanloo, C. Boucherie, D. Gfeller, G. Bader, S. Sidhu, J. Vandekerckhove, and J. Gettemans. "Functional Complexes between Yap2 and Zo-2 Are Pdz Domain-Dependent, and Regulate Yap2 Nuclear Localization and Signalling1." Biochem. J 432, (2010): 461-472.

Parkin, E., and B. Harris. "A Disintegrin and Metalloproteinase (Adam)‐Mediated Ectodomain Shedding of Adam10." Journal of neurochemistry 108, no. 6 (2009): 1464-1479.

Parkin, E.T., C.A. Parr-Sturgess, and D.J. Rushton. "Ectodomain Shedding of the Notch Ligand Jagged1 Is Mediated by Adam17 but Is Not a Lipid Raft-Associated Event." (2010).

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Péréfarres, F., M. Hoareau, F. Chiroleu, B. Reynaud, J. Dintinger, and J.M. Lett. "A Novel Synthetic Quantification Standard Including Virus and Internal Report Targets: Application for the Detection and Quantification of Emerging Begomoviruses on Tomato." Virology Journal 8, no. 1 (2011): 389.

PEREIRA, J.L., G.B. KLAFKE, G. MOREIRA, L.S. PINTO, F.R. CONCEIÇÃO, and F.P. LEITE. "Clonagem E Expressão Da Quimera Ltb/Gnrh Em Pichia Pastoris."

Perez-Jimenez, R., A. Inglés-Prieto, Z.M. Zhao, I. Sanchez-Romero, J. Alegre-Cebollada, P. Kosuri, S. Garcia-Manyes, T.J. Kappock, M. Tanokura, and A. Holmgren. "Single-Molecule Paleoenzymology Probes the Chemistry of Resurrected Enzymes." Nature structural & molecular biology 18, no. 5 (2011): 592-596.

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Pisarev, A.V., A. Unbehaun, C.U.T. Hellen, and T.V. Pestova. "Assembly and Analysis of Eukaryotic Translation Initiation Complexes." Methods in enzymology 430, (2007): 147-177.

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